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227013 CCR4 Antagonist - CAS 864289-85-0 - Calbiochem

The CCR4 Antagonist, also referenced under CAS 864289-85-0, controls the biological activity of CCR4. This small molecule/inhibitor is primarily used for Membrane applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(1,4ʹ-Bipiperidine-1ʹ-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine, C-021

227013
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
864289-85-0C₂₇H₄₁N₅O₂ • 0.5 H₂O
Description
OverviewA cell-permeable diaminoquinazoline compound that acts as a potent antagonist against the G-protein-coupled chemokine receptor CCR4 (IC50 = 73 and 18 nM against CCL22-binding and CCL22-induced GTPγS recruitment, respectively). Shown to inhibit CCL22/CCR4-mediated chemotaxis in both murine and human cultures (IC50 = 39 and 140 nM, respectively).
Catalogue Number227013
Brand Family Calbiochem®
Synonyms2-(1,4ʹ-Bipiperidine-1ʹ-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine, C-021
References
ReferencesYokoyama, K., et al. 2008. Bioorg. Med. Chem. 16, 7021.
Product Information
CAS number864289-85-0
FormLight beige solid
Hill FormulaC₂₇H₄₁N₅O₂ • 0.5 H₂O
Chemical formulaC₂₇H₄₁N₅O₂ • 0.5 H₂O
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
227013 0

Documentation

CCR4 Antagonist - CAS 864289-85-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CCR4 Antagonist - CAS 864289-85-0 - Calbiochem Certificates of Analysis

TitleLot Number
227013

References

Reference overview
Yokoyama, K., et al. 2008. Bioorg. Med. Chem. 16, 7021.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms2-(1,4ʹ-Bipiperidine-1ʹ-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine, C-021
DescriptionA cell-permeable diaminoquinazoline compound that acts as a potent antagonist against the G-protein-coupled chemokine receptor CCR4 (IC50 = 73 and 18 nM against CCL22-binding and CCL22-induced GTPγS recruitment, respectively). Shown to inhibit CCL22/CCR4-mediated chemotaxis in both murine and human cultures (IC50 = 39 and 140 nM, respectively).
FormLight beige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number864289-85-0
Chemical formulaC₂₇H₄₁N₅O₂ • 0.5 H₂O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesYokoyama, K., et al. 2008. Bioorg. Med. Chem. 16, 7021.