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203987 Butein - CAS 487-52-5 - Calbiochem

A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor.

Butein - CAS 487-52-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2ʹ,4ʹ,3,4-Tetrahydroxychalcone

Primary Target: Tyrosine kinase activity of the EGF receptor
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
487-52-5C₁₅H₁₂O₅
Description
OverviewA cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase and rat liver glutathione-S-transferase (IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells.
Catalogue Number203987
Brand Family Calbiochem®
Synonyms2ʹ,4ʹ,3,4-Tetrahydroxychalcone
References
ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
Chan, S.C., et al. 1998. Planta Med. 64, 153.
Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.
Product Information
CAS number487-52-5
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₅H₁₂O₅
Chemical formulaC₁₅H₁₂O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTyrosine kinase activity of the EGF receptor
Primary Target IC<sub>50</sub>65 µM against tyrosine kinase activity of the EGF receptor
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203987 0

Documentation

Butein - CAS 487-52-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Butein - CAS 487-52-5 - Calbiochem Certificates of Analysis

TitleLot Number
203987

References

Reference overview
Howitz, K.T., et al. 2003. Nature 425, 191.
Chan, S.C., et al. 1998. Planta Med. 64, 153.
Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
Synonyms2ʹ,4ʹ,3,4-Tetrahydroxychalcone
DescriptionA cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM) The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase (GSH-RD) and rat liver glutathione S-transferase (GST; IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number487-52-5
Chemical formulaC₁₅H₁₂O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Toxicity Standard Handling
ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
Chan, S.C., et al. 1998. Planta Med. 64, 153.
Yang, E.B., et al. 1998. Biochem. Biophys. Res. Commun. 245, 435.
Zhang, K., et al. 1997. Biochem. Pharmacol. 54, 1047.
Zhang, K., and Das, N.P. 1994. Biochem. Pharmacol. 47, 2063.