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531000 Brk Inhibitor, Cpd 4f - Calbiochem

A cell permeable, highly potent, and very selective inhibitor of breast tumor kinase (Brk; IC₅₀ = 3.15 nM). Displays anti-proliferative activity against multiple breast cancer cell lines.

Brk Inhibitor, Cpd 4f - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PTK6 Inhibitor, Breast Tumor Kinase Inhibitor

Primary Target: Brk
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531000
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇H₁₃N₃O

Products

Catalogue NumberPackaging Qty/Pack
5.31000.0001 Glass bottle 10 mg
Description
OverviewA cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC50 = 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC50 = < 10 µM for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI50 = 990 nM; 1.02 µM, and 1.58 µM for MCF7, HS-578/T, BT-549, respectively).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531000
Brand Family Calbiochem®
SynonymsPTK6 Inhibitor, Breast Tumor Kinase Inhibitor
References
ReferencesMahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.
Product Information
FormLight beige powder
Hill FormulaC₁₇H₁₃N₃O
Chemical formulaC₁₇H₁₃N₃O
Quality LevelMQ100
Applications
Biological Information
Primary TargetBrk
Primary Target IC<sub>50</sub>3.15 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are good for up to 2 weeks at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.31000.0001 04055977242485

Documentation

Brk Inhibitor, Cpd 4f - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Mahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-September-2014 JSW
SynonymsPTK6 Inhibitor, Breast Tumor Kinase Inhibitor
DescriptionA cell permeable pyridoindole based compound that acts as a highly potent and selective inhibitor of breast tumor kinase (Brk; IC50 = 3.15 nM) with minimal or no effect against a panel of more than 30 other protein kinases (IC50 = < 10 µM for PIM2, NEK1 and2, CAMK4, MAPKAPK3 and 5 and MARK1, 3, and 5). Does not affect the activity of Akt isoforms, AGC kinases, ERK1 and 2, JNK 1 and 2 and HIPK isoforms. Displays anti-proliferative activity against multiple breast cancer cell lines (GI50 = 990 nM; 1.02 µM, and 1.58 µM for MCF7, HS-578/T, BT-549, respectively).
FormLight beige powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₁₃N₃O
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are good for up to 2 weeks at -70°C.
Toxicity Standard Handling
ReferencesMahmoud, K. A., et al. 2014. Bioorg. Med. Chem. Lett. 24, 1948.