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200485 Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester

Primary Target: Neutral amino pepsidase
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
65322-89-6C₁₇H₂₆N₂O₄
Description
Overview

This product has been discontinued.



A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays slightly stronger inhibition of neutral aminopeptidase than Bestatin but has much weaker activity against basic aminopeptidase. Also augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.
Catalogue Number200485
Brand Family Calbiochem®
Synonyms(-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester
References
ReferencesSekine, K., et al. 2001. Int. J. Cancer 94, 485.
Product Information
CAS number65322-89-6
ATP CompetitiveN
FormYellowish semi-solid
Hill FormulaC₁₇H₂₆N₂O₄
Chemical formulaC₁₇H₂₆N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNeutral amino pepsidase
Primary Target IC<sub>50</sub>31.6 nM against neutral amino pepsidase
Purity≥97% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
200485 0

Documentation

Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem Certificates of Analysis

TitleLot Number
200485

References

Reference overview
Sekine, K., et al. 2001. Int. J. Cancer 94, 485.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
Synonyms(-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester
DescriptionA cell-permeable derivative of Bestatin (Cat. No. 200484) that displays stronger inhibition of neutral aminopeptidase than Bestatin (IC50 = 31.6 nM). Exhibits weaker activity against basic aminopeptidase (IC50 = 400.1 nM). Also reported to augment Fas- (IC50 = 235.4 nM) or TNF-α-induced apoptosis in solid tumor cell lines.
FormYellowish semi-solid
Intert gas (Yes/No) Packaged under inert gas
CAS number65322-89-6
Chemical formulaC₁₇H₂₆N₂O₄
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityDMSO (100 mg/ml). Unstable in aqueous solution; dilute just prior to use.
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesSekine, K., et al. 2001. Int. J. Cancer 94, 485.