Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

504345 BX471 - CAS 217645-70-0 - Calbiochem

BX471 - CAS 217645-70-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752

Primary Target: CCR1
504345
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
217645-70-0C₂₁H₂₄ClFN₄O₃
Description
OverviewAn orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.
Catalogue Number504345
Brand Family Calbiochem®
SynonymsN-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
References
ReferencesShahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
Reuss, R., et al. 2010. Mult Scler. 16, 366.
Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.
Product Information
CAS number217645-70-0
FormWhite to beige powder
Hill FormulaC₂₁H₂₄ClFN₄O₃
Chemical formulaC₂₁H₂₄ClFN₄O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCCR1
Primary Target K<sub>i</sub>1-5 nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
504345 0

Documentation

BX471 - CAS 217645-70-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

BX471 - CAS 217645-70-0 - Calbiochem Certificates of Analysis

TitleLot Number
504345

References

Reference overview
Shahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
Reuss, R., et al. 2010. Mult Scler. 16, 366.
Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2019 JSW
SynonymsN-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
DescriptionAn orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.
FormWhite to beige powder
CAS number217645-70-0
Chemical formulaC₂₁H₂₄ClFN₄O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (≥25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
Reuss, R., et al. 2010. Mult Scler. 16, 366.
Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.