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189291 Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem

Atorvastatin, Calcium Salt, CAS 134523-03-8, is a cell-permeable, highly potent, and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
134523-03-8[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
Description
Overview

This product has been discontinued.



A cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.
Catalogue Number189291
Brand Family Calbiochem®
Synonyms(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,
References
ReferencesChen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
Law, M.R., et al. 2003. BMJ 326, 1423.
Youssef, S., et al. 2002. Nature 420, 78.
Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.
Product Information
CAS number134523-03-8
FormWhite powder
Hill Formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
Chemical formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationAtorvastatin, Calcium Salt, CAS 134523-03-8, is a cell-permeable, highly potent, and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver).
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
189291 0

Documentation

Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem Certificates of Analysis

TitleLot Number
189291

References

Reference overview
Chen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
Law, M.R., et al. 2003. BMJ 326, 1423.
Youssef, S., et al. 2002. Nature 420, 78.
Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-May-2012 JSW
Synonyms(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,
DescriptionA cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number134523-03-8
Chemical formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml; clear, colorless solution) or Methanol (10 mg/ml; clear, colorless solution) or Ethanol (2 mg/ml; clear, colorless solution). Not soluble in H₂O.
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
Law, M.R., et al. 2003. BMJ 326, 1423.
Youssef, S., et al. 2002. Nature 420, 78.
Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.