Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

533796 Asparagine Endopeptidase Inhibitor, AENK

A specific, competitive inhibitor of the asparagine endopeptidase that suppresses tau cleavage and tetanus toxin antigen processing.

Asparagine Endopeptidase Inhibitor, AENK MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK

Primary Target: AEP
View Products on Sigmaaldrich.com
533796
  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₃H₄₃N₇O₉
Description
OverviewAn amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number533796
Brand Family Calbiochem®
SynonymsFmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK
References
ReferencesZhang, Z., et al. 1999. Nat. Med. 20, 1254.
Monoury, B., et al. 1998. Nat. 396, 695.
Product Information
FormWhite solid
FormulationSupplied as a TFA salt.
Hill FormulaC₃₃H₄₃N₇O₉
Chemical formulaC₃₃H₄₃N₇O₉
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetAEP
Purity≥98% by HPLC
Physicochemical Information
Peptide SequenceFmoc-Ala-Glu-Asn-Lys-NH2
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
533796 0

Documentation

Asparagine Endopeptidase Inhibitor, AENK SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Zhang, Z., et al. 1999. Nat. Med. 20, 1254.
Monoury, B., et al. 1998. Nat. 396, 695.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-July-2016 JSW
SynonymsFmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK
DescriptionAn amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).
FormWhite solid
FormulationSupplied as a TFA salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₃H₄₃N₇O₉
Peptide SequenceFmoc-Ala-Glu-Asn-Lys-NH2
Purity≥98% by HPLC
SolubilityH₂O (25 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesZhang, Z., et al. 1999. Nat. Med. 20, 1254.
Monoury, B., et al. 1998. Nat. 396, 695.