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MABN1725 Anti-Thyroid Hormone Receptor β-1 Antibody, clone N402/46

Anti-Thyroid Hormone Receptor -1, clone N402/46 Antibody, Cat. No. MABN1725, is a highly specific mouse monoclonal antibody that targets Thyroid Hormone Receptor -1 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: THRB, ERBA2, NR1A2, THR1 UniProt Number: P10828
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MABN1725
100 μg  
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Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
R, H, MIH(P), WBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN1725
DescriptionAnti-Thyroid Hormone Receptor β-1 Antibody, clone N402/46
Alternate Names
  • Thyroid hormone receptor beta
  • Nuclear receptor subfamily 1 group A member 2
  • c-erbA-2
  • c-erbA-beta
Background InformationThyroid hormone receptor beta (UniProt: P10828; also known as Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta) is encoded by the THRB (also known as ERBA2, NR1A2, THR1) gene (Gene ID: 7068) in human. Thyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. Thyroid hormone receptor beta is a nuclear hormone receptor that has a transactivation domain at its N-terminal, a ligand-binding domain at the C-terminal, and a DNA-binding domain that binds to sequences of promoter DNA known as hormone response elements. It serves as a high affinity receptor for thyroid hormones, including triiodothyronine (T3) and thyroxine and serves as a hormone-dependent transcriptional regulator that binds DNA sequences and is activated by T3. It plays an important role in vertebrate development, specifically in developing limbs and face. 9-cis-retinoic acid receptor (RXR) and retinoic acid receptor (RAR) receptor families are often associated with thyroid hormone receptor -1 and form homodimers and heterodimers. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Thyroid Hormone Receptor -1, clone N402/46 Antibody, Cat. No. MABN1725, is a highly specific mouse monoclonal antibody that targets Thyroid Hormone Receptor -1 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Thyroid Hormone Receptor -1 in human pancreas and human liver tissue.

Western Blotting Analysis: A representative lot detected Thyroid Hormone Receptor beta-1 in COS cells transiently transfected with Myc-tagged TRalpha1, Myc-tagged TRbeta1, Myc-tagged TRbeta2 or untagged Kv2.1 plasmid. (Courtesy of James Trimmer, Ph.D., University of California at Davis, USA).
Biological Information
ImmunogenA full-length human recombinant Thyroid Hormone Receptor beta-1.
CloneN402/46
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone N402/46 detects Thyroid Hormone Receptor beta-1 in multiple human tissues.
IsotypeIgG1κ
Species Reactivity
  • Rat
  • Human
  • Mouse
Species Reactivity NoteHuman, Mouse, Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • THRB
  • ERBA2
  • NR1A2
  • THR1
Purification MethodProtein G purified
UniProt Number
Molecular Weight~60 kDa observed; 52.79 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human cerebellum tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Thyroid Hormone Receptor -1 in human cerebellum tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABN1725 04054839193545