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AB10440 Anti-PACSIN3 Antibody, NT

Anti-PACSIN3 Antibody, N-terminus is an antibody against PACSIN3 for use in WB, IH(P).

Research Category: Cell Structure Research Sub-Category: Cytoskeletal Signaling Gene Symbol: SDPIII UniProt Number: Q9UKS6
AB10440
100 µg   
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, HWB, IH(P)RbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB10440
DescriptionAnti-PACSIN3 Antibody, NT
Alternate Names
  • Endophilin I
  • SH3 domain-containing protein 6511
  • protein kinase C and casein kinase substrate in neurons 3
  • syndapin III
Background InformationPACSINs are a protein family consisting of three members that have been implicated in synaptic vesicular membrane trafficking and regulation of dynamin-mediated endocytotic processes (Cuajungco, 2006). It is presumed that all isoforms bind Dynamin, Synaptojanin 1 and N-WASP through their Src homology 3 domains. While PACSIN1 appears to be restricted to neural tissues, two PACSINs are more widespread with PACSIN2 being ubiquitously expressed and PACSIN3 present mainly in skeletal muscle, heart and lung (Modregger, 2001). PACSIN3 (protein kinase C and casein kinase substrate in neurons 3) contains a short proline-rich region and lacks asparagine-proline-phenylalanine motifs, that differentiates it from the rest of the PACSIN family. Expected molcular weight is 49 kDa.
References
Product Information
FormatPurified
Control
  • Mouse brain lysate
PresentationPBS containing 0.09% NaN3.
Applications
ApplicationAnti-PACSIN3 Antibody, N-terminus is an antibody against PACSIN3 for use in WB, IH(P).
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Biological Information
ImmunogenKLH conjugated synthetic peptide selected from the N-terminal region of human PACSIN3.
EpitopeN-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThe antibody recognizes human and mouse PACSIN3.
Species Reactivity
  • Mouse
  • Human
Species Reactivity NoteHuman and mouse. Reactivity with other species has not been tested.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SDPIII
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: May play a role in vesicle formation and transport.
SUBUNIT STRUCTURE: Homo- and hetero-aggregates with other PACSINs. Binds dynamin 1, synaptojanin, synapsin 1 and the neural Wiskott-Aldrich syndrome protein (N-WASP). Also interacts with MDC9 and MDC15 By similarity.
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note= Detected at the inner aspect of the plasma membrane in cells or myotubes.
TISSUE SPECIFICTY: Expressed in heart and skeletal muscle, lung, kidney, adrenal gland and placenta.
PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) Probable.
SEQUENCE SIMILARITIES: Belongs to the PACSIN family.
Contains 1 FCH domain.
Contains 1 SH3 domain.
Molecular Weight~53 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated on a representative lot by Western blot on mouse brain lysate using 1:250 dilution of Anti-PACSIN3.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8ºC for up to 6 months from date of receipt. -20ºC is recommended for long term storage.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB10440 04053252743740

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