Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABF114 Anti-MSR1/CD204 Antibody

Anti-MSR1/CD204 is an antibody against MSR1/CD204 for use in WB, FC.

Anti-MSR1/CD204 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: MSR1, SCARA1 UniProt Number: P21757
View Products on Sigmaaldrich.com
ABF114
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, FCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABF114
DescriptionAnti-MSR1/CD204 Antibody
Alternate Names
  • Macrophage scavenger receptor types I and II
  • Macrophage acetylated LDL receptor I and II
  • Scavenger receptor class A member 1
  • CD204
Background InformationMacrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a wide variety of negatively charged macromolecules. There are two types of these receptors that differ in the C-terminal region. MSR has a key role in scavenging a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of MSR is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Ab deposition in Alzheimer's disease (AD).The observation that the 4 allele of the apolipoprotein E gene is associated with an increased risk for AD has lead to the investigation of lipoprotein metabolism in the brain of AD patients. The type I MSR has been found to be expressed on microglia and Mato cells, but not astrocytes or neurons. In AD brain, MSR type I is strongly expressed by microglia cells that are associated with senile plaques. Because the senile plaques contain AGEs, which are a source of free radicals that could result in oxidative damage to the brain, MSR may have a role in mediating the endocytosis of AGEs.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-MSR1/CD204 is an antibody against MSR1/CD204 for use in WB, FC.
Key Applications
  • Western Blotting
  • Flow Cytometry
Application NotesFlow Cytometry Analysis: 1.0 µg of this antibody from a representative lot detected MSR1/CD204 in 1X10E6 K562 myelogenous leukemia cells.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human MSR1/CD204.
EpitopeExtracellular domain
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • MSR1
  • SCARA1
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~42 & ~49 kDa observed. This antibody is predicted to cross-react with all isoforms of MSR1/CD204 (Isoform 1 - ~49 kDa, Isoform 2 - ~40 kDa, and Isoform 3 - ~42 kDa).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in THP-1 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected MSR1/CD204 in 10 µg of THP-1 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABF114 04055977115970