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MABS341 Anti-LRP6 Antibody, clone 1C10

This LRP6 antibody is validated for use in WB & IP for the detection of the LRP6 protein.

Anti-LRP6 Antibody, clone 1C10 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Developmental Signaling Gene Symbol: LRP6 UniProt Number: O75581
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MABS341
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, R, MWB, IPMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS341
DescriptionAnti-LRP6 Antibody, clone 1C10
Alternate Names
  • Low-density lipoprotein receptor-related protein 6
  • LRP-6
Background InformationLow density lipoprotein receptor-related protein 6, also known as LRP6, is a member of the low density Lipoprotein receptor gene family (LDLR). LDLR are cell surface proteins. LRP6 plays a crucial role in embryonic development by functioning as a co-receptor for the Wnt signaling pathway. LRP6 is highly homologous and presents itself as a dimer in the cell membrane until it is phosphlorylated by Wnt. LRP6 has a high affinity with the Dickkopf (DKK) family of antagonists which, when bound, block Wnt. When LRP6 binds to Wnt it is phosphlorated at multiple sites, which results in Axin, a scaffolding protein, being recruited to the cell membrane and β-catenin activation. β-catenin prevents Wnt and LRP6 from binding. LRP6 is associated with autosomal dominant coronary artery disease type 2. Mutations resulting in the omission of the extracellular domain of LPR6 results in constant activity whereas carboxy intracellular domain exclusion has a negative effect, resulting in the blocking of Wnt signaling.
References
Product Information
FormatPurified
Control
  • HEK293 cell lysate
PresentationPurified mouse monoclonal IgG containing PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis LRP6 antibody is validated for use in WB & IP for the detection of the LRP6 protein.
Key Applications
  • Western Blotting
  • Immunoprecipitation
Application NotesImmunoprecipitation Analysis: A representative lot immunoprecipitated LRP6 in certain cell lyates (Khan, Z., et al. (2007). Mol Cell Biol. 27(20):7291-7301.).
Biological Information
ImmunogenFlag-tagged recombinant protein corresponding to human LRP6.
Clone1C10
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG
Species Reactivity
  • Human
  • Rat
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • LRP6
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~200 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected LRP6 in 10 µg of HEK293 cell lysate. For enhanced results, it is recommended for end-users to perform higher dilutions of this antibody.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABS341 04053252858314

Documentation

Anti-LRP6 Antibody, clone 1C10 SDS

Title

Safety Data Sheet (SDS) 

Anti-LRP6 Antibody, clone 1C10 Certificates of Analysis

TitleLot Number
Anti-LRP6, clone 1C10 2475092
Anti-LRP6, clone 1C10 - 2360588 2360588
Anti-LRP6, clone 1C10 - 2384016 2384016
Anti-LRP6, clone 1C10 - 3440264 3440264
Anti-LRP6, clone 1C10 - 3583842 3583842
Anti-LRP6, clone 1C10 - 3683793 3683793
Anti-LRP6, clone 1C10 - 3701823 3701823
Anti-LRP6, clone 1C10 - 3831570 3831570
Anti-LRP6, clone 1C10 - 3860808 3860808
Anti-LRP6, clone 1C10 - 3865646 3865646
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