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MABC552 Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1

This Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Kallikrein-1/KLK1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: KLK1 UniProt Number: P06870
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MABC552
100 μg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC552
Description Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1
Alternate Names
  • Kallikrein-1
  • Kidney/pancreas/salivary gland kallikrein
  • Tissue kallikrein
  • Kallikrein-1/KLK1
Background InformationKallikrein-1 (EC:3.4.21.35; UniProt P06870; also known as Glandular kallikrein 1, hK1, Kallikrein serine protease 1, Kidney/pancreas/salivary gland kallikrein, Renal/pancreas/salivary kallikrein 1, Tissue kallikrein) is encoded by the KLK1 (also known as KLKR) gene (Gene ID 3816) in human. Kallikrein-1 is a member of the kallikrein subfamily of serine proteases, members of which are involved in diverse physiological functions and many are used clinically as biomarkers for cancer. Kallikrein-1 is initially produced as a preproprotein with a signal (aa 1-18) and a propeptide (aa 19-24), cleavage of which releases the mature protein (aa 25-262). Kallikrein-1 is the major kallikrein expressed in the kidney, where it generates kinins (e.g. lysyl-bradykinin and bradykinin) and plays role in kidney function and blood pressure regulation through vasodilatory and natriuretic effects. Decreased kidney Kallikrein-1 level is reported in experimental settings of hypertension, diabetic nephropathy, high salt- and aminoglycoside-induced kidney injury.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Kallikrein-1/KLK1 Antibody, clone 11C7.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Kallikrein-1/KLK1.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein-1/KLK1 in human pancreas and human colon tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the C-terminal half of human Kallikrein-1/KLK1.
EpitopeC-terminal half
Clone11C7.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityExpected to react with both spliced isoforms.
IsotypeIgG2bκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • KLK1
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~30 kDa observed. 28.9 kDa/isoform 1 and 23.8 kDa/isoform 2 calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human salivary gland tissue lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Kallikrein-1/KLK1 in 10 µg of human salivary gland tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC552 04055977276978