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MAB3402B Anti-GFAP Antibody, Biotin Conjugate

Anti-GFAP Antibody, Biotin Conjugate detects level of GFAP & has been published & validated for use in IH.

Anti-GFAP Antibody, Biotin Conjugate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: GFAP UniProt Number: P14136
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MAB3402B
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, H, R, Po, ChIHCMBiotinMonoclonal Antibody
Description
Catalogue NumberMAB3402B
DescriptionAnti-GFAP Antibody, Biotin Conjugate
Alternate Names
  • Glial fibrillary acidic protein
  • GFAP
Background InformationGlial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system.
References
Product Information
FormatBiotin
Control
  • Mouse adult brain tissue
PresentationPurified mouse monoclonal IgG1 conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationAnti-GFAP Antibody, Biotin Conjugate detects level of GFAP & has been published & validated for use in IH.
Key Applications
  • Immunohistochemistry
Biological Information
ImmunogenPurified glial filament protein (Debus, E., et al. (1983) Differentiation. 25:193-203.)
HostMouse
IsotypeIgG1
Species Reactivity
  • Mouse
  • Human
  • Rat
  • Pig
  • Chicken
Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Human, Rat, Porcine, and Chicken based on 100% sequence homology.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Gene Symbol
  • GFAP
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

SIZE: 432 amino acids; 49880 Da

SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.

SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.

DISEASE: Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.

SIMILARITY: Belongs to the intermediate filament family.
Molecular Weight50 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in mouse adult brain tissue.

Immunohistochemistry Analysis: 1:100 dilution of this antibody detected GFAP in mouse adult brain tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB3402B 04053252531422

Documentation

Anti-GFAP Antibody, Biotin Conjugate SDS

Title

Safety Data Sheet (SDS) 

Anti-GFAP Antibody, Biotin Conjugate Certificates of Analysis

TitleLot Number
Anti-GFAP, Biotin Conjugate 2999789
Anti-GFAP, Biotin Conjugate 3158075
Anti-GFAP, Biotin Conjugate 2480935
Anti-GFAP, Biotin Conjugate 2868355
Anti-GFAP, Biotin Conjugate 2920705
Anti-GFAP, Biotin Conjugate 3537156
Anti-GFAP, Biotin Conjugate - 2197241 2197241
Anti-GFAP, Biotin Conjugate - 2301295 2301295
Anti-GFAP, Biotin Conjugate - 2829465 2829465
Anti-GFAP, Biotin Conjugate - 2986137 2986137
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Product Families

Glial Cell Markers

Glial cells, sometimes called neuroglia are non-neuronal cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the brain and peripheral nervous system.
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Categories

Life Science Research > Antibodies and Assays > Primary Antibodies