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05-1529 Anti-FXR1 Antibody, clone 6BG10

Use Anti-FXR1 Antibody, clone 6BG10 (Mouse Monoclonal Antibody) validated in WB, ICC, IP to detect FXR1 also known as fragile X mental retardation autosomal homolog 1.

Anti-FXR1 Antibody, clone 6BG10 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: RNA Metabolism & Binding Proteins, Developmental Signaling Gene Symbol: FXR1, hFXR1 UniProt Number: P51114
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05-1529
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, ICC, IPMPurifiedMonoclonal Antibody
Description
Catalogue Number05-1529
DescriptionAnti-FXR1 Antibody, clone 6BG10
Alternate Names
  • fragile X mental retardation, autosomal homolog 1
  • fragile X mental retardation-related protein 1
Background InformationFragile X mental retardation-related protein 1 (FXR1) and FXR2 are members of the FMR1 family sharing a very high degree of protein similarity among them. They interact with each other and also with FMR1, moving between the cytoplasm and the nucleus. FXR1 is an RNA binding protein and is expressed in the heart, kidney, brain, and testis. Mutations in FMR1 result in the most common form of mental retardation.
References
Product Information
FormatPurified
Control
  • HeLa cell lysate
PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationUse Anti-FXR1 Antibody, clone 6BG10 (Mouse Monoclonal Antibody) validated in WB, ICC, IP to detect FXR1 also known as fragile X mental retardation autosomal homolog 1.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunoprecipitation
Application NotesImmunocytochemistry Analysis: 1:500 dilution from a representative lot detected FXR1 in HeLa and NIH/3T3 cell lysates.

Immunoprecipitation Analysis: A representative lot was used in an independent laboratory in immunoprecipitation. Siomi, M., et al. (1996). Molecular and Cellular Biology. 3825-3832.
Biological Information
ImmunogenRecombinant protein corresponding to human FXR1.
EpitopeUnknown
Clone6BG10
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThis antibody recognizes FXR1.
IsotypeIgG2aκ
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Gene Symbol
  • FXR1
  • hFXR1
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs By similarity.

SUBUNIT STRUCTURE: Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1.

SUBCELLULAR LOCATION: Cytoplasm.

TISSUE SPECIFICTY: Expressed in all tissues examined including heart, brain, kidney and testis.

PTM: Arg-445 is dimethylated, probably to asymmetric dimethylarginine.

SEQUENCE SIMILARITIES: Belongs to the FMR1 family.

Contains 2 KH domains.
Molecular Weight68 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/ml of this antibody detected FXR1 on 10 µg of HeLa cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
05-1529 04053252276415

Documentation

Anti-FXR1 Antibody, clone 6BG10 SDS

Title

Safety Data Sheet (SDS) 

Anti-FXR1 Antibody, clone 6BG10 Certificates of Analysis

TitleLot Number
Anti-FXR1, clone 6BG10 - 2430454 2430454
Anti-FXR1, clone 6BG10 - 2051972 2051972
Anti-FXR1, clone 6BG10 - 2884656 2884656
Anti-FXR1, clone 6BG10 - 3252902 3252902
Anti-FXR1, clone 6BG10 - 3534072 3534072
Anti-FXR1, clone 6BG10 - 3933668 3933668
Anti-FXR1, clone 6BG10 - NG1720745 NG1720745
Anti-FXR1, clone 6BG10 - NG1853781 NG1853781
Anti-FXR1, clone 6BG10 - NG1946561 NG1946561
Anti-FXR1, clone 6BG10 - NRG1655005 NRG1655005
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