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AB3127 Anti-FLT-4 Antibody

Detect FLT-4 using this Anti-FLT-4 Antibody validated for use in ELISA & WB.

Anti-FLT-4 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: FLT4, PCL, VEGFR-3, FLT41, VEGFR3, EC 2.7.10.1 UniProt Number: P35916
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AB3127
50 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MELISA, WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB3127
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-FLT-4 Antibody
Alternate Names
  • VEGF Receptor-3
References
Product Information
FormatAffinity Purified
PresentationLiquid in PBS, containing 0.1% BSA. Affinity purified immunoglobulin.
Quality LevelMQ100
Applications
ApplicationDetect FLT-4 using this Anti-FLT-4 Antibody validated for use in ELISA & WB.
Key Applications
  • ELISA
  • Western Blotting
Application NotesWestern blot: 1-10 μg/mL using ECL. The antibodies detected ~140 kDa band in rat liver extracts.

ELISA: 1:10,000-1:100,000, using 50-100ng of control peptide/well.

Optimal working dilutions must be determined by end user.
Biological Information
Immunogen20 amino acid peptide sequence within the cytoplasmic, C-terminus of mouse Flt-4
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes mouse Flt-4 (mouse 1363-aa and human 1298-aa) a receptor protein tyrosine kinase. It is type 1 membrane protein, a receptor for VEGF-C and is expressed in adult lung, and liver, and in fetal liver, brain, intestine, and placenta. Flt-4 is also known as vascular endothelial growth factor receptor 3 (VEGFR3).

SPECIES REACTIVITIES: The peptide sequence used is relatively conserved in rat (85%) and human (73%) Flt-4/VEGFR3. No significant sequence homology is seen with VEGFR1, VEGFR2, or other tyrosine kinases. Antibody crossreactivity in other species is not established.
Species Reactivity
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • FLT4
  • PCL
  • VEGFR-3
  • FLT41
  • VEGFR3
  • EC 2.7.10.1
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P35916 # Receptor for VEGFC. Has a tyrosine-protein kinase activity.
SIZE: 1298 amino acids; 145599 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain.
DISEASE: SwissProt: P35916 # Defects in FLT4 are the cause of hereditary lymphedema I [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. Hereditary lymphedema I shows autosomal dominant inheritance and is characterized by onset usually at birth. & Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10/% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.
SIMILARITY: SwissProt: P35916 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze and thaw.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB3127 04053252735042

Documentation

Anti-FLT-4 Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-FLT-4 Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-FLT-4 - 3706624 3706624
RABBIT ANTI-FLT-4 AFFINITY-PURIFIED -2510129 2510129
RABBIT ANTI-FLT-4 AFFINITY-PURIFIED -2544302 2544302
RABBIT ANTI-FLT-4 AFFINITY-PURIFIED -2817730 2817730
RABBIT ANTI-FLT-4 AFFINITY-PURIFIED POLYCLONAL ANTIBODY 3045782
RABBIT ANTI-FLT-4 AFFINITY-PURIFIED POLYCLONAL ANTIBODY 2962963
RABBIT ANTI-FLT-4 AFFINITY-PURIFIED POLYCLONAL ANTIBODY - 2074018 2074018

References

Reference overviewPub Med ID
Molecular cloning of murine FLT and FLT4.
Finnerty, H, et al.
Oncogene, 8: 2293-8 (1993)  1993

Show Abstract 		8393164 8393164
FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter
Aprelikova, O, et al
Cancer Res, 52:746-748 (1992)  1992

1310071 1310071

Data Sheet

Title
RABBIT ANTI-FLT-4 AFFINITY-PURIFIED