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ABE792 Anti-FAM120A Antibody

Anti-FAM120A Antibody is an antibody against FAM120A for use in western blotting, IHC & immunofluorescence.

Anti-FAM120A Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: RNA Metabolism & Binding Proteins Gene Symbol: FAM120A, C9orf10, KIAA0183, OSSA UniProt Number: Q9NZB2
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ABE792
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE792
DescriptionAnti-FAM120A Antibody
Alternate Names
  • Constitutive coactivator of PPAR-gamma-like protein 1
  • Oxidative stress-associated Src activator
  • Protein FAM120A
Background InformationConstitutive coactivator of PPAR-gamma-like protein 1, also known as Oxidative stress-associated Src activator or Protein FAM120A, and encoded by the gene name FAM120A or OSSA, was recently detected within the Purα-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A is highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-FAM120A Antibody is an antibody against FAM120A for use in western blotting, IHC & immunofluorescence.
Key Applications
  • Western Blotting
  • Immunohistochemistry
  • Immunofluorescence
Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected FAM120A in rat brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected FAM120A in rat brain cells.
Biological Information
ImmunogenKLH-conjugated synthetic peptide corresponding to the N-terminus of human FAM120A.
EpitopeN-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody will not cross-reacti with FAM120B/PGCC1.
Species Reactivity
  • Human
  • Rat
Antibody TypePolyclonal Antibody
Gene Symbol
  • FAM120A
  • C9orf10
  • KIAA0183
  • OSSA
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~130 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in SK-N-SH cell lysate.

Western Blotting Analysis: 0.5 μg/mL of this antibody detected FAM120A in SK-N-SH cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABE792 04053252945267