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171375 Amphotericin B, Streptomyces sp. - CAS 1397-89-3 - Calbiochem

A polyene antifungal antibiotic that non-specifically induces loss of low molecular weight substances from cells. Binds to sterols and disrupts osmotic integrity of fungal membrane. Causes suppression of bone marrow progenitor cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fungizone

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1397-89-3C₄₇H₇₃NO₁₇
Description
OverviewA polyene antifungal antibiotic that non-specifically induces loss of low molecular weight substances from cells. Binds to sterols and disrupts osmotic integrity of fungal membrane. Causes suppression of bone marrow progenitor cells.
Catalogue Number171375
Brand Family Calbiochem®
SynonymsFungizone
References
ReferencesTollemar, J., et al. 1995. Transplantation 59, 45.
Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
Barth, C., et al. 1993. J. Biophys. 64, 92.
Product Information
CAS number1397-89-3
FormYellow solid
Hill FormulaC₄₇H₇₃NO₁₇
Chemical formulaC₄₇H₇₃NO₁₇
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity>86% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSBU2625000
Safety Information
R PhraseR: 20/21-36/37/38

Harmful by inhalation and in contact with skin.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Solutions in tissue culture media are stable for 3 days at 37°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
171375 0

Documentation

Amphotericin B, Streptomyces sp. - CAS 1397-89-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Amphotericin B, Streptomyces sp. - CAS 1397-89-3 - Calbiochem Certificates of Analysis

TitleLot Number
171375

References

Reference overview
Tollemar, J., et al. 1995. Transplantation 59, 45.
Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
Barth, C., et al. 1993. J. Biophys. 64, 92.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-July-2007 RFH
SynonymsFungizone
DescriptionAn antifungal agent. A polyene antibiotic that nonspecifically induces the loss of low molecular weight substances from cells. Causes suppression of bone marrow progenitor cells. Probably forms channels by complexing with membrane cholesterol. Effective against fungi and yeast at concentrations of 1-10 µg/ml.
FormYellow solid
CAS number1397-89-3
RTECSBU2625000
Chemical formulaC₄₇H₇₃NO₁₇
Structure formulaStructure formula
Purity>86% by HPLC
SolubilityDMF or DMSO (30-40 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Solutions in tissue culture media are stable for 3 days at 37°C.
Toxicity Harmful
Merck USA index14, 585
ReferencesTollemar, J., et al. 1995. Transplantation 59, 45.
Charak, B.S., et al. 1994. Br. J. Haematol. 88, 693.
Barth, C., et al. 1993. J. Biophys. 64, 92.