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116819 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Chloro-, Rp-Isomer, Sodium Salt

A cell-permeable, metabolically-stable analog of cAMP that acts as a competitive inhibitor of protein kinase A.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Rp-8-Cl-cAMPS, Na, PKA Inhibitor IX

Primary Target: PKA 1
116819
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
142754-27-6C₁₀H₁₀ClN₅O₅PS · Na
Description
Overview

This product has been discontinued.





A cell-permeable, metabolically-stable analog of cAMP that acts as a competitive inhibitor of protein kinase A. Lipophilic analog of the cAMP antagonist Rp-cAMPS (Cat. No. 116814). Preferentially inhibits type I PKA (IC50 = ~50 µM).
Note: 5 µmol = 2 mg.
Catalogue Number116819
Brand Family Calbiochem®
SynonymsRp-8-Cl-cAMPS, Na, PKA Inhibitor IX
References
ReferencesBraun, C.M., et al. 1998. Biochem Pharmacol. 56, 871.
Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
Yokazaki, H., et al. 1992. Cancer Res. 52, 2504.
Product Information
CAS number142754-27-6
ATP CompetitiveY
DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
FormLyophilized
Hill FormulaC₁₀H₁₀ClN₅O₅PS · Na
Chemical formulaC₁₀H₁₀ClN₅O₅PS · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetPKA 1
Primary Target IC<sub>50</sub>50 µM against PKA 1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
116819 0

Documentation

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Chloro-, Rp-Isomer, Sodium Salt SDS

Title

Safety Data Sheet (SDS) 

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Chloro-, Rp-Isomer, Sodium Salt Certificates of Analysis

TitleLot Number
116819

References

Reference overview
Braun, C.M., et al. 1998. Biochem Pharmacol. 56, 871.
Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
Yokazaki, H., et al. 1992. Cancer Res. 52, 2504.

Technical Info

Title
Anaerocult®IS - 116819
Anaerocult®IS - 116819
Anaerocult®IS - 116819
Anaerocult®IS, 116819 MIBIO
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-September-2007 RFH
SynonymsRp-8-Cl-cAMPS, Na, PKA Inhibitor IX
DescriptionA cell-permeable, metabolically stable cAMP analog that acts as a competitive inhibitor of PKA (protein kinase A). Preferentially inhibits type I PKA (IC50 ~50 µM). Inhibits cholera toxin- and prostaglandin E1-induced apoptosis in IPC leukemia cells (IC50 ~300 µM). More lipophilic than the parent compound, Rp-cAMPS (Cat. No. 116814). Note: 5 µmol = 2 mg.
FormLyophilized
CAS number142754-27-6
Chemical formulaC₁₀H₁₀ClN₅O₅PS · Na
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBraun, C.M., et al. 1998. Biochem Pharmacol. 56, 871.
Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
Yokazaki, H., et al. 1992. Cancer Res. 52, 2504.