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116812 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem

Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt

Primary Target: Protein kinase A and protein kinase G
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116812
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Overview

Key Spec Table

CAS #Empirical Formula
93882-12-3C₁₆H₁₄ClN₅O₆PS · Na

Products

Catalogue NumberPackaging Qty/Pack
116812-10MG Plastic ampoule 10 mg
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Description
OverviewCell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50 = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50 = 25 µM).
Catalogue Number116812
Brand Family Calbiochem®
SynonymsAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
References
Referencesde Rooij, J., et al. 1998. Nature. 396, 474.
Kawasaki, H., et al. 1998. Science. 282, 2275.
Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
Datta, R., et al. 1991. Blood 78, 83.
Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
Sandberg, M., et al. 1991. Biochem. J. 279, 521.
Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
Xu, H., et al. 1989. Brain Res. 504, 36.
Product Information
CAS number93882-12-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₆H₁₄ClN₅O₆PS · Na
Chemical formulaC₁₆H₁₄ClN₅O₆PS · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetProtein kinase A and protein kinase G
Primary Target IC<sub>50</sub>900 nM against cGMP-specific phosphodiesterase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C
Global Trade Item Number
Catalogue Number GTIN
116812-10MG 04055977208238