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114666 Actinomycin D, Streptomyces sp. - CAS 50-76-0 - Calbiochem

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Overview

Key Spec Table

CAS #Empirical Formula
50-76-0C₆₂H₈₆N₁₂O₁₆
Description
OverviewAnti-neoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. At higher concentrations, DNA polymerase is inhibited. Also acts as a competitive inhibitor of serine proteases. Inhibits cell growth and colony formation in synchronized HeLa cells. Induces apoptosis in many cell lines. However, actinomycin D has also been shown to suppress etoposide-induced apoptosis in PC12 cells. Note: 1 set = 20 x 200 µg.
Stability: heat resistant and stable between pH 2 and 11. Decomposed by strong acids and bases.
Catalogue Number114666
Brand Family Calbiochem®
SynonymsDactinomycin, RNA Polymerase I Inhibitor I, Pol I Inhibitor I
References
ReferencesNakajima, M., et al. 1994. Neurosci. Lett. 176, 161.
Wu, M.H., and Yung, B.Y. 1994. Eur. J. Pharmacol. 270, 203.
Betzel, C., et al. 1993. Biochim. Biophys. Acta 1161, 47.
Yung, B.Y., et al. 1992. Int. J. Cancer 52, 317.
Martin, S.J., et al. 1990. J. Immunol. 145, 1859.
Yung, B.Y., et al. 1990. Cancer Res. 50, 5987.
White, R.J., and Phillips, D.R. 1985. Biochemistry 27, 9122.
Madharavao, M., et al. 1978. J. Med. Chem. 21, 958.
Sengupta, S.K., et al. 1975. J. Med. Chem. 18, 1175.
Product Information
CAS number50-76-0
FormRed crystalline solid
Hill FormulaC₆₂H₈₆N₁₂O₁₆
Chemical formulaC₆₂H₈₆N₁₂O₁₆
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationActinomycin D, Streptomyces sp., CAS 50-76-0, is an anti-neoplastic antibiotic that inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues.
Biological Information
Primary Targetserine proteases
Secondary targetcell growth and colony formation in synchronized HeLa cells
Purity≥98% by HPLC
Safety Information according to GHS
RTECSAU1575000
Safety Information
R PhraseR: 28

Very toxic if swallowed.
S PhraseS: 28-36/37-45


Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
114666 0