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658460 AG 879 - CAS 148741-30-4 - Calbiochem

AG 879 - CAS 148741-30-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide

Primary Target: (NGF)-dependent p140c-trk tyrosine phosphorylation
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
148741-30-4C₁₈H₂₄N₂OS
Description
Overview

This product has been discontinued.



A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation (EC50 = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner.
Catalogue Number658460
Brand Family Calbiochem®
Synonymsα-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
References
ReferencesKonrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
Product Information
CAS number148741-30-4
ATP CompetitiveN
FormOrange-yellow solid
Hill FormulaC₁₈H₂₄N₂OS
Chemical formulaC₁₈H₂₄N₂OS
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target(NGF)-dependent p140c-trk tyrosine phosphorylation
Primary Target IC<sub>50</sub>EC50 = 10 µM inhibiting nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



From Catalog:
Solubility- removed acetic acid, MeOH
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
658460 0

Documentation

AG 879 - CAS 148741-30-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AG 879 - CAS 148741-30-4 - Calbiochem Certificates of Analysis

TitleLot Number
658460

References

Reference overview
Konrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-May-2011 RFH
Synonymsα-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
DescriptionA cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent pp140c-trk tyrosine phosphorylation (EC50 = 10 µM), as well as NGF-induced phospholipase C-γ1 phosphorylation. Also shown to inhibit HER2 (IC50 = 1 µM). Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Also inhibits insulin secretion in a dose-dependent manner.
FormOrange-yellow solid
CAS number148741-30-4
Chemical formulaC₁₈H₂₄N₂OS
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityAcetic acid, DMSO (100 mg/ml), or methanol
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



From Catalog:
Solubility- removed acetic acid, MeOH
Toxicity Standard Handling
ReferencesKonrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry 32, 4650.