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658402 AG 527

AG 527 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)

658402
  
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Overview

Replacement Information
Description
OverviewA cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 2.5 µM). Also inhibits phosphorylation of poly-GAT by the EGF receptor (IC50 = 400 nM).
Catalogue Number658402
Brand Family Calbiochem®
Synonyms(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)
References
ReferencesGazit, A., et al. 1991. J. Med. Chem. 34, 1896.
Product Information
CAS number133550-32-0
FormYellow solid
Hill FormulaC₁₈H₁₆N₂O₃
Chemical formulaC₁₈H₁₆N₂O₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetepidermal growth factor (EGF) receptor kinase autophosphorylation
Primary Target IC<sub>50</sub>2.5 µM
Secondary targetphosphorylation of poly-GAT by the EGF receptor (IC₅₀ = 400 nM)
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
658402 0

Documentation

AG 527 Certificates of Analysis

TitleLot Number
658402

References

Reference overview
Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
Synonyms(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide, α-Cyano-(-)-(R)-N-(α-phenethyl)-3,4-dihydroxycinnamide, Tyrphostin B44(-)
DescriptionA cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor kinase autophosphorylation (IC50 = 2.5 µM). Also inhibits the phosphorylation of poly-GAT by the EGF receptor (IC50 = 400 nM).
FormYellow solid
CAS number133550-32-0
Chemical formulaC₁₈H₁₆N₂O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesGazit, A., et al. 1991. J. Med. Chem. 34, 1896.