504317 Sigma-Aldrich5-Azacytidine - CAS 320-67-2 - Calbiochem
Recommended Products
Overview
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
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| 320-67-2 | C₈H₁₂N₄O₅ |
| Description | |
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| Overview | This product has been discontinued. A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50 < 4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826). |
| Catalogue Number | 504317 |
| Brand Family | Calbiochem® |
| Synonyms | 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, 5'AzaC, 5-Azacitidine, Zcyd |
| References | |
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| References | Hollenbach, P.W., et al. 2010. PLoS ONE 5, e9001. Huangfu, D., et al. 2008. Nat. Biotech. 26, 795. Christman, J.K., 2002. Oncogene 21, 5483. |
| Product Information | |
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| CAS number | 320-67-2 |
| Form | Off-white powder |
| Hill Formula | C₈H₁₂N₄O₅ |
| Chemical formula | C₈H₁₂N₄O₅ |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | DNA & RNA |
| Purity | ≥93% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 45-46 May cause cancer. May cause heritable genetic damage. |
| S Phrase | S: 22-36/37/39 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 504317 | 0 |
Documentation
5-Azacytidine - CAS 320-67-2 - Calbiochem SDS
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References
| Reference overview |
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| Hollenbach, P.W., et al. 2010. PLoS ONE 5, e9001. Huangfu, D., et al. 2008. Nat. Biotech. 26, 795. Christman, J.K., 2002. Oncogene 21, 5483. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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