Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

441251 α₂-Macroglobulin, Human Plasma - Calbiochem

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases.

α₂-Macroglobulin, Human Plasma - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α₂M, α₂MG

Primary Target: broad range protease
View Products on Sigmaaldrich.com
441251
Purchase on Sigma-Aldrich

Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
441251-10MG Plastic ampoule 10 mg
441251-1MG Plastic ampoule 1 mg
Description
OverviewA multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
Catalogue Number441251
Brand Family Calbiochem®
Synonymsα₂M, α₂MG
References
ReferencesBonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
Lysiak, J.J., et al. 1995. J. Biol. Chem. 270, 21919.
Boisset, N., et al. 1992. J. Struct. Biol. 108, 221.
Barrett, A.J. 1980. Methods Enzymol. 80, 737.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationLyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetbroad range protease
Purity≥95% by SDS-PAGE
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
441251-10MG 04055977206005
441251-1MG 04055977205992

Documentation

α₂-Macroglobulin, Human Plasma - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

α₂-Macroglobulin, Human Plasma - Calbiochem Certificates of Analysis

TitleLot Number
441251

References

Reference overview
Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
Lysiak, J.J., et al. 1995. J. Biol. Chem. 270, 21919.
Boisset, N., et al. 1992. J. Struct. Biol. 108, 221.
Barrett, A.J. 1980. Methods Enzymol. 80, 737.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-August-2008 RFH
Synonymsα₂M, α₂MG
DescriptionA multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α2M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
FormLyophilized
FormulationLyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity≥95% by SDS-PAGE
SolubilityAqueous buffers
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
Lysiak, J.J., et al. 1995. J. Biol. Chem. 270, 21919.
Boisset, N., et al. 1992. J. Struct. Biol. 108, 221.
Barrett, A.J. 1980. Methods Enzymol. 80, 737.