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531619 2-Aminopurine - CAS 452-06-2 - Calbiochem

2-Aminopurine - CAS 452-06-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-AP, 2AP

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
452-06-2C₅H₅N₅
Description
Overview

This product has been discontinued.



A cell permeable adenine analog that is widely used as a versatile fluorescent probe to investigate RNA and DNA secondary and tertiary structures and their conformation dynamics in response to local environment when interacting with other biomolecules with great sensitivity. Forms stable base pairs with neucleobase uracil found in RNA and thymine in DNA, and moderately stable base pairs with cytosine. Exhibits intensive fluorescence emission (lAbsmax = 303 nM, lflmax = 370 nM, and fluorescence quantum yield in solution QFI = 0.68) and longer excitation wavelength compared with other neucleobases enabling its selective excitation with low background signals.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Catalogue Number531619
Brand Family Calbiochem®
Synonyms2-AP, 2AP
References
ReferencesMa, L., et al. 2014. Biochem. Biophys. Res. Comm. 449, 120.
Widom, J. R., et al. 2013. New. J. Phys. 15, 025028.
Souliere, M. F., et al. 2011. J. Am. Chem. Soc. 133, 16161,
Jean, J. M., et al. 2001. PNAS 98,37.
Product Information
CAS number452-06-2
FormYellow powder
Hill FormulaC₅H₅N₅
Chemical formulaC₅H₅N₅
ReversibleY
Quality LevelMQ200
Applications
Biological Information
Primary TargetDNA and RNA
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Emission max.
Excitation max.
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
531619 0

Documentation

2-Aminopurine - CAS 452-06-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Ma, L., et al. 2014. Biochem. Biophys. Res. Comm. 449, 120.
Widom, J. R., et al. 2013. New. J. Phys. 15, 025028.
Souliere, M. F., et al. 2011. J. Am. Chem. Soc. 133, 16161,
Jean, J. M., et al. 2001. PNAS 98,37.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-December-2014 JSW
Synonyms2-AP, 2AP
DescriptionA cell permeable adenine analog that is widely used as a versatile fluorescent probe to investigate RNA and DNA secondary and tertiary structures and their conformation dynamics in response to local environment when interacting with other biomolecules with great sensitivity. Forms stable base pairs with neucleobase uracil found in RNA and thymine in DNA, and moderately stable base pairs with cytosine. Exhibits intensive fluorescence emission (lAbsmax = 303 nM, lflmax = 370 nM, and fluorescence quantum yield in solution QFI = 0.68) and longer excitation wavelength compared with other neucleobases enabling its selective excitation with low background signals.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number452-06-2
Chemical formulaC₅H₅N₅
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesMa, L., et al. 2014. Biochem. Biophys. Res. Comm. 449, 120.
Widom, J. R., et al. 2013. New. J. Phys. 15, 025028.
Souliere, M. F., et al. 2011. J. Am. Chem. Soc. 133, 16161,
Jean, J. M., et al. 2001. PNAS 98,37.