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112251
Sigma-Aldrichα₁-Acid Glycoprotein, Human Plasma
Native α1-acid glycoprotein from human plasma. Glycoprotein used for the study of the structure of oligosaccharide units. Consists of 40 - 45% carbohydrate. Present in human plasma at concentrations of 55 - 140 mg/100 ml. Clinically,α1-AG is an acute-phase reactant that, together with haptoglobin, indicates acute inflammation. Selectively suppresses the augmentation of NK cell activity by IFN-α and IFN-γ. Theα1-AG:α1-antitrypsin ratio is useful in diagnosis of liver disease. A sialic acid-deficientα1-AG has been observed in serum or urine of patients with Hodgkin’s disease, psoriatic arthritis, diabetes, and chronic myeloid leukemia. Sialic acid-deficientα1-AG has an affinity for vitamin B12.
Catalogue Number
112251
Brand Family
Calbiochem®
Synonyms
α₁-AG, C-AGP, Orosomucoid, α₁M-Seromucoid
References
References
Aso, H., et al. 1999. Inflammation 23, 117. Schmid, K., et al. 1973. Biochemistry 12, 2711.
α₁-Acid Glycoprotein, Human Plasma Certificates of Analysis
Title
Lot Number
112251
References
Reference overview
Aso, H., et al. 1999. Inflammation 23, 117. Schmid, K., et al. 1973. Biochemistry 12, 2711.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
01-December-2011 JSW
Synonyms
α₁-AG, C-AGP, Orosomucoid, α₁M-Seromucoid
Description
Native α1-acid glycoprotein from human plasma. Glycoprotein used for the study of the structure of oligosaccharide units. Consists of 40-45% carbohydrate. Present in human plasma at concentrations of 55-140 mg/100 ml. Clinically, α1-AG is an acute phase reactant that, together with haptoglobin, indicates acute inflammation. Selectively suppresses the augmentation of NK cell activity by IFN-α and IFN-γ. The α1-AG:α1-antitrypsin ratio is useful in diagnosis of liver disease. A sialic acid-deficient α1-AG has been observed in serum or urine of patients with Hodgkin's disease, psoriatic arthritis, diabetes, and chronic myeloid leukemia. Sialic acid-deficient α1-AG has an affinity for vitamin B12.
Form
Lyophilized
Source
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number
66455-27-4
Purity
≥95% by SDS-PAGE
Solubility
Aqueous buffers (1 mg/ml)
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for to 3 months at (-20°C).
Toxicity
Standard Handling
References
Aso, H., et al. 1999. Inflammation 23, 117. Schmid, K., et al. 1973. Biochemistry 12, 2711.
