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565780 β-Secretase Inhibitor III - Calbiochem

The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

β-Secretase Inhibitor III - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Inhibitor GL189, H-EVNstatineVAEF-NH₂

Primary Target: BACE
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565780
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₄₄H₇₀N₁₀O₁₄

Products

Catalogue NumberPackaging Qty/Pack
565780-500UG Plastic ampoule 500 μg
Description
OverviewA substrate analog inhibitor of β-secretase (BACE) that completely blocks the proteolytic activity (at 5 µM) in solubilized membrane fractions from BACE transfected MDCK cells.
Catalogue Number565780
Brand Family Calbiochem®
SynonymsInhibitor GL189, H-EVNstatineVAEF-NH₂
References
ReferencesCapell, A., et al. 2002. J. Biol. Chem. 277, 5637.
Tung, J.S., et al. 2002. J. Med. Chem. 45, 259.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₄₄H₇₀N₁₀O₁₄
Chemical formulaC₄₄H₇₀N₁₀O₁₄
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetBACE
Primary Target IC<sub>50</sub>Effective concentration: 5 µM completely blocking the proteolytic activity of β-secretase (BACE) in solubilized membrane fractions from BACE transfected MDCK cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565780-500UG 04055977267280

Documentation

β-Secretase Inhibitor III - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

β-Secretase Inhibitor III - Calbiochem Certificates of Analysis

TitleLot Number
565780

References

Reference overview
Capell, A., et al. 2002. J. Biol. Chem. 277, 5637.
Tung, J.S., et al. 2002. J. Med. Chem. 45, 259.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-September-2008 RFH
SynonymsInhibitor GL189, H-EVNstatineVAEF-NH₂
DescriptionA substrate analog inhibitor of β-secretase (BACE) that completely blocks proteolytic activity in solubilized membrane fractions of BACE-transfected MDCK cells at a concentration of 5 µM.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₄H₇₀N₁₀O₁₄
Peptide SequenceH-Glu-Val-Asn-Statine-Val-Ala-Glu-Phe-NH₂
Purity≥95% by HPLC
SolubilityDMSO (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCapell, A., et al. 2002. J. Biol. Chem. 277, 5637.
Tung, J.S., et al. 2002. J. Med. Chem. 45, 259.