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407318 β-Interferon, Human, Recombinant, CHO Cells

β-Interferon, Human, Recombinant, CHO Cells MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Interferon α-2 precursor, IFN-β-1a, rHuIFN-β-1a

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Overview

Replacement Information
Description
Overview

This product has been discontinued.



Recombinant, human interferon-β (IFN-β) expressed in CHO cells as a single glycosylated polypeptide containing 166 amino acids. Purified by chromatographic methods. IFN-β is a type I cytokine produced in response to exposure to viruses or double-stranded RNAs. It is also induced by other cytokines, such as TNF and IL-1. It is involved in the regulation of non-specific humoral immune responses and immune responses to viral infections, and thus exhibits anti-viral, anti-proliferative, and immunomodulating properties. The biological activity of IFN-β, unlike IFN-α, is strictly species-specific and will not be active across species.
Catalogue Number407318
Brand Family Calbiochem®
SynonymsInterferon α-2 precursor, IFN-β-1a, rHuIFN-β-1a
References
ReferencesGoebel, M.U., et al. 2005. Physiol. Behav. 84, 807.
Graber, J., et al. 2005. J. Neuroimmunol. 161,169.
Mallada-Frechin, J., et al. 2005. Rev. Neurol. 40, 482.
Patten, S.B., et al. 2005. Mult. Scler. 11, 175.
Pohl, D., et al. 2005. Neurology 64, 888.
Schwid, S.R., et al. 2005. Arch. Neurol. 62, 785.
Product Information
FormLyophilized
FormulationLyophilized from 62 mg/ml mannitol, 9.1 mg/ml human albumin, 0.9 mg/ml acetate, pH 7.0-7.2.
Quality LevelMQ100
Applications
Biological Information
Biological activityReported as IU/mg on a lot-specific basis using a viral resistance assay
Purity≥98% by SDS-PAGE
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 7 days at 4°C or for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
407318 0

Documentation

β-Interferon, Human, Recombinant, CHO Cells SDS

Title

Safety Data Sheet (SDS) 

β-Interferon, Human, Recombinant, CHO Cells Certificates of Analysis

TitleLot Number
407318

References

Reference overview
Goebel, M.U., et al. 2005. Physiol. Behav. 84, 807.
Graber, J., et al. 2005. J. Neuroimmunol. 161,169.
Mallada-Frechin, J., et al. 2005. Rev. Neurol. 40, 482.
Patten, S.B., et al. 2005. Mult. Scler. 11, 175.
Pohl, D., et al. 2005. Neurology 64, 888.
Schwid, S.R., et al. 2005. Arch. Neurol. 62, 785.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-May-2009 JSW
SynonymsInterferon α-2 precursor, IFN-β-1a, rHuIFN-β-1a
DescriptionRecombinant, human interferon-β (IFN-β) expressed in CHO cells as a single glycosylated polypeptide containing 166 amino acids. Purified by chromatographic methods. IFN-β is a type I cytokine produced in response to exposure to viruses or double-stranded RNAs. It is also induced by other cytokines, such as TNF and IL-1. It is involved in the regulation of non-specific humoral immune responses and immune responses to viral infections, and thus exhibits anti-viral, anti-proliferative, and immunomodulating properties. The biological activity of IFN-β, unlike IFN-α, is strictly species-specific and will not be active across species.
FormLyophilized
FormulationLyophilized from 62 mg/ml mannitol, 9.1 mg/ml human albumin, 0.9 mg/ml acetate, pH 7.0-7.2.
Purity≥98% by SDS-PAGE
Biological activityReported as IU/mg on a lot-specific basis using a viral resistance assay
SolubilityReconstitute with sterile water to ≥100 µg/ml, containing 0.1% HSA or BSA. Further dilute with aqueous buffer just prior to use.
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 7 days at 4°C or for up to 4 months at -20°C. Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesGoebel, M.U., et al. 2005. Physiol. Behav. 84, 807.
Graber, J., et al. 2005. J. Neuroimmunol. 161,169.
Mallada-Frechin, J., et al. 2005. Rev. Neurol. 40, 482.
Patten, S.B., et al. 2005. Mult. Scler. 11, 175.
Pohl, D., et al. 2005. Neurology 64, 888.
Schwid, S.R., et al. 2005. Arch. Neurol. 62, 785.