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14-658 WNK3 Protein, active, 10 µg

Active, N-terminal 6His-tagged, recombinant, human WNK3, amino acids 1-434, for use in Kinase Assays.

WNK3 Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-658
10 µg  
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      Overview

      Replacement Information
      Description
      Catalogue Number14-658
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionWNK3 Protein, active, 10 µg
      OverviewN-terminal 6His-tagged, recombinant, human WNK3, amino acids 1-434
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human WNK3, amino acids 1-434, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
      Entrez Gene Number
      Entrez Gene SummaryMembers of the 'with no lysine' (WNK) kinase family, such as WNK3, are serine-threonine protein kinases that lack the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. Instead, these kinases have a conserved lysine in subdomain I that is thought to provide this function (Holden et al., 2004 [PubMed 15194194]).[supplied by OMIM]
      Gene Symbol
      • WNK3
      • KIAA1566
      • PRKWNK3
      Protein TargetWNK3
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryCOFACTOR: Magnesium (By similarity).
      SIZE: 1743 amino acids; 191789 Da
      TISSUE SPECIFICITY: Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen.
      SIMILARITY: SwissProt: Q9BYP7 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. & Contains 1 protein kinase domain.
      Molecular Weight53.1kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of MBP (#13-104).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-658 04053252509186

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      Alternative Packsize

      Catalogue Number Description  
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases