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108219 Tris(hydroxymethyl)aminomethane hydrochloride

Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1214-684-5C₄H₁₁NO₃˙ ClHC₄H₁₁NO₃*ClH157.60 g/mol

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
1082190003
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      Fibre case 3 x 0,750 kg
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      1082191000
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          1082191003
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              1082195000
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                  Plastic bottle 5 kg
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                  1082199010
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                      Plastic drum 10 kg
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                      1082199012
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                          Bucket, plastic 12 kg
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                          1082199013
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                              Bucket, plastic 12 kg
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                              1082199050
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                                  Plastic drum 50 kg
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                                  Description
                                  Catalogue Number108219
                                  SynonymsTrometamol, Aminomethylidine trimethanol, 2-Amino-2-hydroxymethyl-1.3-propanediol, TRIS-buffer
                                  DescriptionTris(hydroxymethyl)aminomethane hydrochloride
                                  References
                                  Product Information
                                  CAS number1185-53-1
                                  EC number214-684-5
                                  Hill FormulaC₄H₁₁NO₃˙ ClH
                                  Chemical formulaC₄H₁₁NO₃*ClH
                                  Molar Mass157.60 g/mol
                                  HS Code2922 19 99
                                  Structure formula ImageStructure formula Image
                                  Quality LevelMQ500
                                  Applications
                                  Biological Information
                                  Physicochemical Information
                                  Density1.28 g/cm3 (20.2 °C)
                                  Melting Point150.7 °C
                                  pH value4.2 (100 g/l, H₂O, 20 °C)
                                  Vapor pressure<0.1 hPa (50 °C)
                                  Solubility561 g/l soluble
                                  Dimensions
                                  Materials Information
                                  Toxicological Information
                                  Safety Information according to GHS
                                  Safety Information
                                  Product Usage Statements
                                  Storage and Shipping Information
                                  Packaging Information
                                  Transport Information
                                  Supplemental Information
                                  Specifications
                                  Appearancewhite to almost white, crystalline powder
                                  Assay (alkalimetric, calculated on dried substance)≥ 99.0 %
                                  Identity (IR-spectrum)conforms
                                  pH-value (0.5 mol/l, water)3.5 - 5.0
                                  Melting point147 - 153 °C
                                  UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
                                  UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
                                  UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
                                  UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
                                  UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
                                  Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
                                  Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
                                  Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
                                  Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
                                  Other residual solvents (ICH Q3C)excluded by manufacturing process
                                  Sulfated ash≤ 0.03
                                  Loss on Drying (105°C)≤ 0.5
                                  Endotoxins< 2.5
                                  Total aerobic microbial count≤ 10²
                                  Total yeast and mould count
                                  ≤ 10²
                                  Salmonella spp.
                                  absent in 10 g
                                  E.coli
                                  absent in 1 g
                                  Staphylococcus aureus
                                  absent in 1 g
                                  Pseudomonas aeruginosa
                                  absent in 1 g
                                  Candida albicans
                                  absent in 1 g
                                  Bile tolerante gram negative bacteria
                                  absent in 1 g
                                  DNases (Exo- and endonucleases)
                                  not detected
                                  Proteases
                                  not detected
                                  RNases
                                  not detected
                                  Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                                  Total yeast and mould count
                                  ≤ 10²
                                  Salmonella spp.
                                  absent in 10 g
                                  E.coli
                                  absent in 1 g
                                  Staphylococcus aureus
                                  absent in 1 g
                                  Pseudomonas aeruginosa
                                  absent in 1 g
                                  Candida albicans
                                  absent in 1 g
                                  Bile tolerante gram negative bacteria
                                  absent in 1 g
                                  DNases (Exo- and endonucleases)
                                  not detected
                                  Proteases
                                  not detected
                                  RNases
                                  not detected
                                  Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
                                  Global Trade Item Number
                                  Catalogue Number GTIN
                                  1082190003 04027269296049
                                  1082191000 04022536101811
                                  1082191003 04027269196462
                                  1082195000 04022536532899
                                  1082199010 04022536702742
                                  1082199012 04027269285586
                                  1082199013 04027269285593
                                  1082199050 04054839392443

                                  Documentation

                                  Material Qualification Dossier

                                  TitleVersion
                                  7.1

                                  Quality Management Dossier (Open Access)

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                                  Operational Excellence Dossier

                                  Title

                                  Tris(hydroxymethyl)aminomethane hydrochloride SDS

                                  Title

                                  Safety Data Sheet (SDS) 

                                  Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

                                  Product Number PackagingSpecificationLot Number
                                  1082190003 Fibre casePDF Specification Document
                                  1082191000 Plastic bottlePDF Specification Document
                                  1082191003 Plastic bottlePDF Specification Document
                                  1082195000 Plastic bottlePDF Specification Document
                                  1082199010 Plastic drumPDF Specification Document
                                  1082199012 Bucket, plasticPDF Specification Document
                                  1082199013 Bucket, plasticPDF Specification Document
                                  1082199050 Plastic drumPDF Specification Document

                                  Certificates

                                  Title