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23-057 Smac/DIABLO

Smac/DIABLO MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Enzyme Assays Entrez Gene Number: NM_019887
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23-057
10 µg  
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      Overview

      Replacement Information
      Description
      Catalogue Number23-057
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSmac/DIABLO
      Alternate Names
      • Diablo homolog, mitochondrial
      • Direct IAP-binding protein with low pI
      • Second mitochondria-derived activator of caspase (Smac)
      Background InformationSmac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along with cytochrome c and other pro-apoptotic factors. Once in the cytosol, Smac/DIABLO binds to inhibitors of apoptosis (IAP) proteins and disrupts the ability of the IAPs to inhibit caspases 3, 7, and 9 thereby promoting apoptosis. Along with several other pro-apoptotic proteins, Smac/DIABLO has been shown to be a substrate for the ubiquitin ligase XIAP.
      References
      Product Information
      Quality LevelMQ100
      Applications
      Key Applications
      • Enzyme Assays
      Biological Information
      Cascade ComponentSubstrate
      Entrez Gene Number
      Purification MethodPurified using immobilized metal affinity chromatography
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      23-057 04053252919060

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      23-057M Smac/DIABLO Show Pricing & Availability

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      Categories

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