566320 Sigma-AldrichSirtinol - CAS 410536-97-9 - Calbiochem
A cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1.
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Synonyms: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 410536-97-9 | C₂₆H₂₂N₂O₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 566320-5MG |
|
Plastic ampoule | 5 mg |
|
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| Description | |
|---|---|
| Overview | A cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1 (IC50 = 48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively). Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM), and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 70 µM and 40 µM, respectively). A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566321) in DMSO is also available. |
| Catalogue Number | 566320 |
| Brand Family | Calbiochem® |
| Synonyms | 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III |
| References | |
|---|---|
| References | Mai, A., et al. 2005. J. Med. Chem. 48, 7789. Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837. |
| Product Information | |
|---|---|
| CAS number | 410536-97-9 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₂₆H₂₂N₂O₂ |
| Chemical formula | C₂₆H₂₂N₂O₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Human HDAC1 |
| Primary Target IC<sub>50</sub> | 48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2 |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 566320-5MG | 04055977191370 |