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14-462M Rsk3 Protein, active, 250 µg

Active, N-terminal His6-tagged recombinant full-length, human RSK3, for use in Kinase Assays.

Rsk3 Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-462M
250 µg  Also available in 10 μg size (cat#14-462) and in bulk (cat# 14-462-K).
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      Overview

      Description
      Catalogue Number14-462M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionRsk3 Protein, active, 250 µg
      OverviewN-terminal His6-tagged recombinant full-length, human RSK3
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal His6-tagged recombinant full-length, human RSK3, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
      Gene Symbol
      • RPS6KA2
      • S6K-alpha
      • RSK-3
      • MAPKAPK1C
      • RSK3
      • S6K-alpha2
      • pp90RSK3
      • HU-2
      • RSK
      • p90-RSK3
      Protein TargetRsk3
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15349 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
      COFACTOR: Magnesium.
      SIZE: 733 amino acids; 83239 Da
      SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
      SUBCELLULAR LOCATION: Nucleus.
      TISSUE SPECIFICITY: Expressed in many tissues. Highest expression in lung and skeletal muscle.
      PTM: Autophosphorylated on Ser-377, as part of the activation process (By similarity).
      SIMILARITY: SwissProt: Q15349 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
      Molecular Weight87kDa
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of the MAPKAP Kinase 2 substrate peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-462) and in bulk (cat# 14-462-K).
      Global Trade Item Number
      Catalogue Number GTIN
      14-462M 04053252278105