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524751 Phosphodiesterase 7A1, Human, Recombinant, S. frugiperda

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: hPDE7A1

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524751
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Overview

Replacement Information

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524751-10U
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      Description
      OverviewFull-length, recombinant, human phosphodiesterdase 7A1 (PDE7A1) expressed in S. frugiperda insect cells using a baculovirus expression system. PDE7A1 is required for T-cell activation induced by the costimulation of CD3 and CD28 receptors. Increased PDE7A1 correlates with a decrease in cAMP, increased IL-2, and increased cell proliferation. Supplied as a partially purified preparation of catalytically active enzyme useful for inhibitor and activator assays.
      Catalogue Number524751
      Brand Family Calbiochem®
      SynonymshPDE7A1
      Application Data
      Increasing concentrations of SB36207, a PDE7A1 inhibitor, were mixed with the enzyme and the activity was measured.
      References
      ReferencesHan, P., et al. 2006. J. Biol. Chem. 281, 15050.
      Lugnier, C. 2006. Pharmacol Ther. 109, 366.
      Bloom, T.J., and Beavo, J.A. 1996. Proc. Natl. Acad. Sci. U S A 93, 14188.
      Product Information
      Activity≥ 0.5 U/µl
      Unit of DefinitionOne unit is defined as the amount of enzyme that is required to convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.
      FormLiquid
      FormulationIn 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.
      Quality LevelMQ100
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      524751-10U 04055977197099

      Documentation

      Phosphodiesterase 7A1, Human, Recombinant, S. frugiperda SDS

      Title

      Safety Data Sheet (SDS) 

      Phosphodiesterase 7A1, Human, Recombinant, S. frugiperda Certificates of Analysis

      TitleLot Number
      524751

      References

      Reference overview
      Han, P., et al. 2006. J. Biol. Chem. 281, 15050.
      Lugnier, C. 2006. Pharmacol Ther. 109, 366.
      Bloom, T.J., and Beavo, J.A. 1996. Proc. Natl. Acad. Sci. U S A 93, 14188.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2008 JSW
      SynonymshPDE7A1
      Application Data
      Increasing concentrations of SB36207, a PDE7A1 inhibitor, were mixed with the enzyme and the activity was measured.
      DescriptionFull-length, recombinant, human phosphodiesterdase 7A1 (PDE7A1) expressed in S. frugiperda insect cells using a baculovirus expression system. PDE7A1 is required for T-cell activation induced by the costimulation of CD3 and CD28 receptors. Increased PDE7A1 correlates with a decrease in cAMP, increased IL-2, and increased cell proliferation. Supplied as a partially purified preparation of catalytically active enzyme useful for inhibitor and activator assays.
      FormLiquid
      FormulationIn 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.
      Activity≥ 0.5 U/µl
      Unit definitionOne unit is defined as the amount of enzyme that is required to convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesHan, P., et al. 2006. J. Biol. Chem. 281, 15050.
      Lugnier, C. 2006. Pharmacol Ther. 109, 366.
      Bloom, T.J., and Beavo, J.A. 1996. Proc. Natl. Acad. Sci. U S A 93, 14188.