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516620
Sigma-AldrichPeroxynitrite - Calbiochem
Peroxynitrite, CAS 14042-01-4, is a cell-permeable, short-lived, strong biological oxidant agent that reacts with and can damage DNA, membrane phospholipids, sulfhydryl groups, and tyrosine.
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Peroxynitrite - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
Synthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a cell-permeable strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. Has been implicated in a variety of pathophysiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock.
Note: 1 set = 2 x 1 ml.
Catalogue Number
516620
Brand Family
Calbiochem®
References
References
Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA94, 14243. Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476. Lymar, S.V., et al. 1996. Biochemistry 35, 7855. Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322. Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.
Peroxynitrite, CAS 14042-01-4, is a cell-permeable, short-lived, strong biological oxidant agent that reacts with and can damage DNA, membrane phospholipids, sulfhydryl groups, and tyrosine.
Biological Information
Primary Target
Oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine
Physicochemical Information
Cell permeable
Y
Safety Information
R Phrase
R: 8-20/22-34
Contact with combustible material may cause fire. Harmful by inhalation and if swallowed. Causes burns.
S Phrase
S: 3-28-36/37/39-45
Keep in a cool place.
Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Oxidizer
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
≤ -70°C
Protect from Light
Protect from light
Avoid freeze/thaw
Avoid freeze/thaw
Do not freeze
Ok to freeze
Special Instructions
Protect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
26-November-2007 JSW
Description
Synthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. It has been implicated in a variety of patho-physiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. This product decomposes or isomerizes at pH 8 or less; the half-life at pH 7.5 is ~1.5 s. ε302 nm = 1670M-1cm-1 in 0.1 MNaOH.
Form
Yellow liquid
Formulation
Supplied in 4.7% NaOH at 160-200 mM.
Intert gas (Yes/No)
Packaged under inert gas
Solubility
Peroxynitrite is soluble in aqueous buffers that have been pre-purged with an inert gas and pre-cooled to 4°C.
Storage
Protect from light Avoid freeze/thaw ≤ -70°C
Do Not Freeze
Ok to freeze
Special Instructions
Protect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C.
Toxicity
Oxidizer
References
Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA94, 14243. Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476. Lymar, S.V., et al. 1996. Biochemistry 35, 7855. Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322. Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.
