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540213 PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem

The PTP Inhibitor V, PHPS1, also referenced under CAS 314291-83-3, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation

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Synonyms: PhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, 4-(Nʹ-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL Inhibitor I, PTP1B Inhibitor V, SHP1 Inhibitor VI, SHP2 Inhibitor III

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540213
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Overview

Key Spec Table

CAS #Empirical Formula
314291-83-3C₂₁H₁₅N₅O₆S

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540213-10MG
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      Description
      OverviewA cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. Shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.
      Catalogue Number540213
      Brand Family Calbiochem®
      SynonymsPhenylHydrazonoPyrazolone Sulfonate 1, PTPNN1 Inhibitor, 4-(Nʹ-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1,5-dihydro-pyrazol-(4Z)-ylidene)-hydrazino)-benzenesulfonic acid, EC-PTP/PCPTP1 Inhibitor I, MptpA Inhibitor, PTP-SL Inhibitor I, PTP1B Inhibitor V, SHP1 Inhibitor VI, SHP2 Inhibitor III
      References
      ReferencesHellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 7275.
      Product Information
      CAS number314291-83-3
      FormReddish solid
      Hill FormulaC₂₁H₁₅N₅O₆S
      Chemical formulaC₂₁H₁₅N₅O₆S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      540213-10MG 04055977268683