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20-120 PKA Inhibitor Peptide

20-120
1 mL  
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      Overview

      Replacement Information
      Description
      Catalogue Number20-120
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPKA Inhibitor Peptide
      References
      Product Information
      Presentation20mM MOPS, pH 7.2, 25mM β-glycerophosphate, 5mM EGTA, 1mM sodium orthovanadate, 1mM dithiothreitol.
      Quality LevelMQ100
      Applications
      ApplicationThe PKA Inhibitor Peptide controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Biochemicals applications.
      Key Applications
      • Kinase Assay
      Application NotesFor use as an inhibitor in kinase assays.
      Biological Information
      Entrez Gene Number
      Entrez Gene SummarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
      Gene Symbol
      • PRKACA
      • MGC102831
      • MGC48865
      • PKACA
      Protein TargetPKA C-alpha
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
      SIZE: 351 amino acids; 40590 Da
      SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
      TISSUE SPECIFICITY: Isoform 2 is sperm specific.
      PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
      SIMILARITY: SwissProt: P17612 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size1 mL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      20-120 04053252405846

      Documentation

      PKA Inhibitor Peptide SDS

      Title

      Safety Data Sheet (SDS) 

      PKA Inhibitor Peptide Certificates of Analysis

      TitleLot Number
      PKA Inhibitor Peptide - 2974519 2974519
      PKA Inhibitor Peptide - Any-lot Any-lot
      PKA Inhibitor Peptide -2632981 2632981
      PKA Inhibitor Peptide -2661525 2661525

      References

      Reference overviewPub Med ID
      Ethanol enhances the endothelial nitric oxide synthase response to agonists.
      R K Davda,L J Chandler,F T Crews,N J Guzman
      Hypertension  21  1993

      Show Abstract
      7685006 7685006
      Glycyl-L-glutamine stimulates the accumulation of A12 acetylcholinesterase but not of nicotinic acetylcholine receptors in quail embryonic myotubes by a cyclic AMP-independent mechanism.
      H S Lotwick,L W Haynes,J Ham
      Journal of neurochemistry  54  1990

      Show Abstract
      2156012 2156012

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