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14-910M PI3K-C2γ Protein, 250 µg

N-terminal GST-tagged recombinant human PI3K-C2γ, amino acids 468–1203, for use in Kinase Assays.

PI3K-C2γ Protein, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-910M
250 µg  Also available in 10 μg size (cat#14-910) and in bulk (cat# 14-910-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-910M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI3K-C2γ Protein, 250 µg
      OverviewN-terminal GST-tagged recombinant human PI3K-C2γ amino acids 468–1203
      References
      Product Information
      Presentation0.54mg/ml of enzyme in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
      Quality LevelMQ100
      Applications
      ApplicationN-terminal GST-tagged recombinant human PI3K-C2γ, amino acids 468–1203, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.
      Gene Symbol
      • PI3-kinase
      • PIK3
      • PI3K
      • PTDINS-3-kinase
      • PI3K C2g
      • PI3-Kinase Class II
      • PIK3C2G
      Protein TargetPI3K-C2γ
      Purification MethodGlutathione agarose affinity chromatography
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummaryFUNCTION: In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2
      CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
      SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein
      TISSUE SPECIFICITY: Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.
      SIMILARITY: Belongs to the PI3/PI4-kinase family. Contains 1 C2 domain. Contains 1 PI3K/PI4K domain. Contains 1 PX (phox homology) domain.
      Molecular Weight112kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in the PIProfiler.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-910) and in bulk (cat# 14-910-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-910M 04053252410130

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-910 PI3K-C2γ Protein, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases