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528116 PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem

The PI 3-Kα Inhibitor VIII controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII

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528116
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
372196-77-5C₁₆H₁₄N₅O₄SBr • HCl • 2H₂O

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      Description
      OverviewA cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110α-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110α, p110γ, PI 3-K C2β, and p110β, respectively). Shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 ≤58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
      Catalogue Number528116
      Brand Family Calbiochem®
      SynonymsN-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII
      References
      ReferencesKim, S., et al. 2007. Blood 110, 4206.
      Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
      Knight, Z.A., et al. 2007. Cell 125, 733.
      Product Information
      CAS number372196-77-5
      FormPale yellow solid
      Hill FormulaC₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
      Chemical formulaC₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      528116-5MG 04055977196993

      Documentation

      PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      528116

      References

      Reference overview
      Kim, S., et al. 2007. Blood 110, 4206.
      Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
      Knight, Z.A., et al. 2007. Cell 125, 733.

      Posters

      Title
      Human Kinome & InhibitorSelect™ Libraries
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-December-2013 JSW
      SynonymsN-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII
      DescriptionA cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110α-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110α, p110γ, PI 3-K C2β, and p110β, respectively). Shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 ≤58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number372196-77-5
      Chemical formulaC₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesKim, S., et al. 2007. Blood 110, 4206.
      Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
      Knight, Z.A., et al. 2007. Cell 125, 733.