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Buffer Detection Kit for Magnetic Beads
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399250
Sigma-AldrichNG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem
Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.
More>>Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
Cell permeable. A key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. A potent inhibitor of liver and macrophage arginase (Ki = 150 µM).
Catalogue Number
399250
Brand Family
Calbiochem®
Synonyms
NOHA, AcOH
References
References
Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614. Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun.193, 963. Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun.187, 880. Stuehr, D.J., et al. 1991. J. Biol. Chem.266, 6259. Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun.176, 528. Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA88, 11172.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
30-October-2023 JSW
Synonyms
NOHA, AcOH
Description
Cell-permeable. A key intermediate product in the biosynthesis of nitric oxide from arginine by constitutive nitric oxide synthase (cNOS). Formed by the NADPH-dependent hydroxylation of L-arginine. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450, providing an alternative biosynthetic route for the production of nitric oxide. A potent inhibitor of liver and macrophage arginase (Ki = 150 µM).
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
53598-01-9
Chemical formula
C₆H₁₄N₄O₃ · CH₃CO₂H
Structure formula
Purity
≥98% by HPLC
Solubility
H₂O (1 mg/ml)
Storage
-20°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Boucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614. Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun.193, 963. Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun.187, 880. Stuehr, D.J., et al. 1991. J. Biol. Chem.266, 6259. Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun.176, 528. Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA88, 11172.
