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399250 NG-Hydroxy-L-arginine, Monoacetate Salt - CAS 53598-01-9 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
53598-01-9C₆H₁₄N₄O₃ · CH₃CO₂H

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399250-5MG
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      Description
      OverviewCell permeable. A key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system. A potent inhibitor of liver and macrophage arginase (Ki = 150 µM).
      Catalogue Number399250
      Brand Family Calbiochem®
      SynonymsNOHA, AcOH
      References
      ReferencesBoucher, J.L., et al. 1994. Biochem. Biophys. Res. Commun. 203, 1614.
      Pufahl, R.A., and Marletta, M.A. 1993. Biochem. Biophys. Res. Commun. 193, 963.
      Boucher, J.L., et al. 1992. Biochem. Biophys. Res. Commun. 187, 880.
      Stuehr, D.J., et al. 1991. J. Biol. Chem. 266, 6259.
      Wallace, G.C., et al. 1991. Biochem. Biophys. Res. Commun. 176, 528.
      Zembowicz, A., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 11172.
      Product Information
      CAS number53598-01-9
      FormWhite solid
      Hill FormulaC₆H₁₄N₄O₃ · CH₃CO₂H
      Chemical formulaC₆H₁₄N₄O₃ · CH₃CO₂H
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetliver and macrophage arginase
      Primary Target K<sub>i</sub>150 µM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      399250-5MG 04055977212556