474790 Sigma-AldrichMG-132 - CAS 133407-82-6 - Calbiochem
A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM).
More>> A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM). Less<<Synonyms: Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI
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Overview
Key Spec Table
CAS # | Empirical Formula |
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133407-82-6 | C₂₆H₄₁N₃O₅ |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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474790-10MG |
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Plastic ampoule | 10 mg |
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474790-1MG |
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Plastic ampoule | 1 mg |
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474790-20MG |
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20 mg |
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474790-5MG |
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Plastic ampoule | 5 mg |
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Description | |
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Overview | A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available. This material is ≥98% pure by HPLC. A material with ≥95% purity by HPLC (Cat. No. 474787) is also available. |
Catalogue Number | 474790 |
Brand Family | Calbiochem® |
Synonyms | Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI |
Product Information | |
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CAS number | 133407-82-6 |
ATP Competitive | N |
Form | White solid |
Hill Formula | C₂₆H₄₁N₃O₅ |
Chemical formula | C₂₆H₄₁N₃O₅ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | proteasome |
Primary Target IC<sub>50</sub> | 3 µM against NF-κB activation |
Primary Target K<sub>i</sub> | 4 nM against proteasome |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Peptide Sequence | Z-Leu-Leu-Leu-CHO |
Global Trade Item Number | |
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Catalogue Number | GTIN |
474790-10MG | 04055977185485 |
474790-1MG | 07790788050436 |
474790-20MG | 04055977185492 |
474790-5MG | 07790788050443 |