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428020 Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem

Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Actin polymerization
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428020
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
76343-94-7C₂₀H₂₉NO₅S

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      428020-5MG
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          Description
          OverviewA structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes; 10 to 100-fold more potent than cytochalasins.
          Catalogue Number428020
          Brand Family Calbiochem®
          References
          ReferencesSpector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
          de Oliveira, C.A., and Mantovani, B. 1988. Life Sci. 43, 1825.
          Coue, M., et al. 1987. FEBS Lett. 213, 316.
          Spector, I., et al. 1983. Science 219, 493.
          Product Information
          CAS number76343-94-7
          ATP CompetitiveN
          FormOff-white to yellow solid
          Hill FormulaC₂₀H₂₉NO₅S
          Chemical formulaC₂₀H₂₉NO₅S
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetActin polymerization
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          428020-1MG 04055977210453
          428020-5MG 04055977210460

          Documentation

          Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          428020

          References

          Reference overview
          Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
          de Oliveira, C.A., and Mantovani, B. 1988. Life Sci. 43, 1825.
          Coue, M., et al. 1987. FEBS Lett. 213, 316.
          Spector, I., et al. 1983. Science 219, 493.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-January-2011 JSW
          DescriptionA structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.
          FormOff-white to yellow solid
          CAS number76343-94-7
          Chemical formulaC₂₀H₂₉NO₅S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml), Methanol (50 mg/ml),or Ethanol (25 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 5378
          ReferencesSpector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
          de Oliveira, C.A., and Mantovani, B. 1988. Life Sci. 43, 1825.
          Coue, M., et al. 1987. FEBS Lett. 213, 316.
          Spector, I., et al. 1983. Science 219, 493.