420360 Sigma-AldrichKMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem
The KMO Inhibitor I, Ro 61-8048, also referenced under CAS 199666-03-0, controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.
More>> The KMO Inhibitor I, Ro 61-8048, also referenced under CAS 199666-03-0, controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048, Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 199666-03-0 | C₁₇H₁₅N₃O₆S₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 420360-10MG |
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Glass bottle | 10 mg |
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| Description | |
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| Overview | A cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki = 4.8 nM; IC50 = 37 nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available (Cat. No. 420361). |
| Catalogue Number | 420360 |
| Brand Family | Calbiochem® |
| Synonyms | Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048, Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide |
| Product Information | |
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| CAS number | 199666-03-0 |
| Form | Yellow solid |
| Hill Formula | C₁₇H₁₅N₃O₆S₂ |
| Chemical formula | C₁₇H₁₅N₃O₆S₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥99% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 420360-10MG | 04055977187557 |
Documentation
KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem SDS
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KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 420360 |
References
| Reference overview |
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| Campesan, S., et al. 2011. Chem. Biol. 21, 961. Zwilling, D., et al. 2011. Cell 145, 863. Giorgini, F., et al. 2005. Nat. Genet. 37, 526. Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab. 19, 771, Rover, S., et al. 1997. J. Med. Chem. 40, 4378. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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