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407272 Integrin αvβ3 Antagonist, P11 - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₃₀H₅₁N₁₂O₉₃· 3TFA

Pricing & Availability

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407272-5MG
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      Description
      OverviewA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
      Catalogue Number407272
      Brand Family Calbiochem®
      SynonymsHSDVHK-NH2, HSDVHK
      References
      ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
      Choi, Y., et al. 2010. Proteomics 10, 72.
      Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
      Product Information
      FormWhite solid
      FormulationSupplied as a trifluoracetate salt.
      Hill FormulaC₃₀H₅₁N₁₂O₉₃· 3TFA
      Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      407272-5MG 04055977188769