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218705 InSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem

The InSolution™ Casein Kinase I Inhibitor, D4476 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: CK1, CK1d
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218705
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₃H₁₈N₄O₃

Pricing & Availability

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218705-1MG
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      		 Plastic ampoule 1 mg
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      Description
      Catalogue Number218705
      Brand Family Calbiochem®
      References
      ReferencesRena, G., et al. 2004. EMBO Reports 5, 60.
      Product Information
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
      Hill FormulaC₂₃H₁₈N₄O₃
      Chemical formulaC₂₃H₁₈N₄O₃
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCK1, CK1d
      Primary Target IC<sub>50</sub>0.2 µM, 0.3 µM against CK1, CK1d, respectively
      Purity≥95% by HPLC
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      218705-1MG 04055977202540

      Documentation

      InSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem Certificates of Analysis

      TitleLot Number
      218705

      References

      Reference overview
      Rena, G., et al. 2004. EMBO Reports 5, 60.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2023 JSW
      DescriptionA cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38α MAP kinase (IC50 = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
      FormLiquid
      FormulationA 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
      Intert gas (Yes/No) Packaged under inert gas
      Concentration Label Please refer to vial label for lot-specific concentration
      Chemical formulaC₂₃H₁₈N₄O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Irritant
      ReferencesRena, G., et al. 2004. EMBO Reports 5, 60.