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407616 IL-1R Antagonist - CAS 566914-00-9 - Calbiochem

IL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic

Primary Target: TIR domain-mediated MyD88/IL1-RI interaction
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407616
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Overview

Key Spec Table

CAS #Empirical Formula
566914-00-9C₁₈H₂₆N₂O₂

Pricing & Availability

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407616-10MG
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      407616-25MG
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          Description
          OverviewA cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
          Catalogue Number407616
          Brand Family Calbiochem®
          SynonymsBB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
          References
          ReferencesBartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.
          Product Information
          CAS number566914-00-9
          ATP CompetitiveN
          FormColorless oil
          Hill FormulaC₁₈H₂₆N₂O₂
          Chemical formulaC₁₈H₂₆N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationIL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.
          Biological Information
          Primary TargetTIR domain-mediated MyD88/IL1-RI interaction
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalogue Number GTIN
          407616-10MG 04055977211337
          407616-25MG 04055977211344