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400046 Hydroxyurea - CAS 127-07-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
127-07-1CH₄N₂O₂

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400046-5GM
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      Description
      OverviewAnti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
      Catalogue Number400046
      Brand Family Calbiochem®
      SynonymsRibonucleotide Reductase Inhibitor I, RNR Inhibitor I
      References
      ReferencesLeyden, D., et al. 2000. Anticancer Res. 20, 133.
      Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
      Anand, S., et al. 1995. Cancer Lett. 88, 101.
      Product Information
      CAS number127-07-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaCH₄N₂O₂
      Chemical formulaCH₄N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetInhibiting ribonucleotide reductase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSYT4900000
      Safety Information
      R PhraseR: 46-61

      May cause heritable genetic damage.
      May cause harm to the unborn child.
      S PhraseS: 45-53

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.
      Global Trade Item Number
      Catalogue Number GTIN
      400046-5GM 04055977212129