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368055 Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Caspase-8 Inhibitor I, Ac-IETD-CHO

Primary Target: caspase-8
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368055
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Overview

Key Spec Table

CAS #Empirical Formula
1258003-96-1C₂₁H₃₄N₄O₁₀

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368055-1MG
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      Description
      OverviewA potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).
      Catalogue Number368055
      Brand Family Calbiochem®
      SynonymsCaspase-8 Inhibitor I, Ac-IETD-CHO
      References
      ReferencesGao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.
      Product Information
      CAS number1258003-96-1
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₂₁H₃₄N₄O₁₀
      Chemical formulaC₂₁H₃₄N₄O₁₀
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetcaspase-8
      Primary Target K<sub>i</sub>1 nM against caspase-8
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Ile-Glu-Thr-Asp-CHO
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      368055-1MG 04055977192131