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14-644M EphA3 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end. For use in Kinase Assays.

14-644M
250 µg  Also available in 10 μg size (cat#14-644) and in bulk (cat#14-644-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-644M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionEphA3 Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human EphA3 amino acids 578-end. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman EphA3 amino acids 578-end, expressed by baculovirus in Sf21 insect cells.
      Entrez Gene Number
      Entrez Gene SummaryThis gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.
      Gene Symbol
      • EPHA3
      • HEK4
      • ETK1
      • HEK
      • TYRO4
      • ETK
      • EphA3
      Protein TargetEphA3
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29320 # Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.
      SIZE: 983 amino acids; 110131 Da
      SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
      TISSUE SPECIFICITY: Widely expressed. Highest level in placenta.
      DISEASE:SwissProt: P29320 # Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].
      SIMILARITY: SwissProt: P29320 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
      Molecular Weight49kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-644) and in bulk (cat#14-644-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-644M 04053252924521

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-644 EphA3 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases