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324410
Sigma-AldrichDynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem
Dynamin Inhibitor I, Dynasore, CAS 304448-55-3, is a cell-permeable inhibitor of the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. Has no significant effect on MxA and Cdc42.
More>>Dynamin Inhibitor I, Dynasore, CAS 304448-55-3, is a cell-permeable inhibitor of the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. Has no significant effect on MxA and Cdc42. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
Catalogue Number
324410
Brand Family
Calbiochem®
Synonyms
3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
References
References
Young, A., et al. 2009. Biochem. J., In press. Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607. Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955. Macia. E., et al. 2006. Dev. Cell10, 839.
Dynamin Inhibitor I, Dynasore, CAS 304448-55-3, is a cell-permeable inhibitor of the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. Has no significant effect on MxA and Cdc42.
Biological Information
Purity
≥98% by HPLC
Safety Information
R Phrase
R: 50
Very toxic to aquatic organisms.
S Phrase
S: 22-24/25
Do not breathe dust. Avoid contact with skin and eyes.
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Environmental Hazard
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Global Trade Item Number
Catalogue Number
GTIN
324410-10MG
04055977197167
Documentation
Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem SDS
Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem Certificates of Analysis
Title
Lot Number
324410
References
Reference overview
Young, A., et al. 2009. Biochem. J., In press. Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607. Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955. Macia. E., et al. 2006. Dev. Cell10, 839.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
20-May-2009 RFH
Synonyms
3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
Description
A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
Form
Pale yellow solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
304448-55-3
Chemical formula
C₁₈H₁₄N₂O₄
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (16 mg/ml)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Environmental Hazard
References
Young, A., et al. 2009. Biochem. J., In press. Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607. Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955. Macia. E., et al. 2006. Dev. Cell10, 839.
